The Association of Aging-Related Polymorphisms with Susceptibility to Lung Cancer: A Case-Control Study in a Japanese Population

Background: Telomere length is associated with cancer as well aging. Telomerase reverse transcriptase (TERT), telomere RNA component (TERC) and oligonucleotide/oligosaccharide-binding fold containing 1 (OBFC1) are known to be involved in regulation. The tumor suppressor p53 (TP53), which has been shown interact protein p53-binding (TP53BP1), implicated the response shortening Polymorphisms TP53 TP53BP1 genes various types of cancer. aim this study evaluate impact aging-related polymorphisms on lung risk. Materials Methods: This case-control consists 462 cases 379 controls from Japan. We examined effect TERT rs2736100, TERC rs1881984, OBFC1 rs11191865, rs1042522 rs560191 risk using a Taq-Man real-time PCR assay. Unconditional logistic regression was used assess adjusted odds ratios (ORs) 95% confidence intervals (CIs). Results: None main effects any telomere-related were related Similarly, none interactive smoking significant multiplicative interaction between rs2736100 statistically (OR for = 0.34, CI 0.14–0.84). rs11191865 also 2.44, 1.02–5.87) but OR opposite direction. Conclusions: Our findings indicate that may predispose depending genotypes polymorphisms. Additional studies warranted confirm suggested present study.